TF-miRNA co-regulatory network analysis demonstrated that FOXM1, MYB, SOX4, miR-21/19b and their FFLs FOXM1-miR-21-5p-CDC25A and MYB/SOX4-miR-19b-3p-RBBP8 may play important roles in the cell proliferation of T-ALL. Here, TF is linked to acute lymphoblastic leukemia.