To examine the possible association between uPA and PAI-1 tumor tissue levels with classical prognostic factors within a group with favorable prognosis we chose tumor size (less or equal to 20 mm vs. greater than 20 mm but less or equal to 30 mm vs. greater than 30 mm), tumor grade (grade 1 vs. grade 2/3), ER level (higher of equal to 50% vs. ER less than 50% of positive cells), and Ki67 level (less than 15% vs. higher or equal to 15% of positive cells). This evidence concerns the gene ESR1 and neoplasm.