The results of the present study are in line with previously published work showing that inhibition of Btk protected against acute lung injury evoked by polymicrobial sepsis (Zhou et al., 2014), the combination of lipopolysaccharide and immune complexes (Krupa et al., 2014) or the combination of trauma and hemorrhagic shock (Liu et al., 2017). This evidence concerns the gene BTK and Sepsis.