FOXO3 and rhabdomyosarcoma: In alveolar rhabdomyosarcoma (ARMS), the FOXO1 gene (13q14.11) is fused to either PAX3 (t(2;13)) or PAX7 (t(1;13)) genes [50], and the chromosomal translocation involving the MLL gene and FOXO3 (6q21) or FOXO4 (Xq13.1) genes (t(6;11); t(X;11)) have been found in secondary leukemia and acute lymphoblastic leukemia, respectively [51,52].