Various compounds such as the atypical retinoid ST1926, the histone deacetylase inhibitor entinostat, the proteasome inhibitor bortezomib, the Gsk3 inhibitor TWS119, as well as the topoisomerase I poison camptotecin were found to be able to reduce the level of the fusion protein Pax3-FoxO1 in ARMS [57,58,59,60,61]. The gene discussed is FOXO1; the disease is alveolar rhabdomyosarcoma.