Along this way, a deregulation of the canonical Mitogen-Activated Protein Kinase (MAPK)/Erk1/2 pathway was identified in breast cancer and in Hodgkin’s lymphoma, whereas the Ikk pathway emerged in acute myeloid leukemia and lung cancer as an important regulator of FoxO3 [11]. The gene discussed is FOXO3; the disease is acute myeloid leukemia.