In addition, in ARMS cells treated with the proteasome inhibitor bortezomib, Marshall et al. [61] reported that the pro-apoptotic BH3-only family member Noxa is upregulated by the Pax3-FoxO1 oncoprotein and that the enhanced expression renders fusion protein-expressing cells more sensitive to apoptosis induced by bortezomib. Here, FOXO1 is linked to alveolar rhabdomyosarcoma.