The nuclear translocation of FoxO1 has been associated with the upregulation of c-Myc via the recruitment of epigenetic regulators, including the Myeloid/Lymphoid Leukemia 2 (KMT2D) and the histone acetyltransferase GCN5, that result in reduced sensitivity to the HER2 EGF-R dual kinase inhibitor lapatinib in Her2-overexpressing breast cancer cells [81]. Here, ERBB2 is linked to breast carcinoma.