In addition, trastuzumab was reported to induce miRNA-542-3p expression, which mediates G1/S checkpoint arrest and in turn reduces proliferation in breast cancer cells [84]; conversely, the down-regulation of miRNA-542-3p has been associated with trastuzumab resistance via PI3K/Akt pathway-mediated activation of FoxO1a level [84]. This evidence concerns the gene AKT1 and breast cancer.