RHBDF2 and Alzheimer disease: The authors also identified genes whose RNA expression was altered in AD including ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2. ANKYRIN 1 (ANK1) and RHOMBOID5 (RHBDF2) genes are involved in the protein tyrosine kinase 2-beta (PTK2B) gene network, a LOAD gene that is a key element of the calcium-induced signaling cascade involved in modulating the activation of microglia and macrophages, as well as in the transport of TNFα converting enzyme (ADAM17) from the cell surface.