EP300 and Alzheimer disease: Patrick and coworkers [8] studied the role of miRNA-132, miRNA-129 and miRNA-99 in the dorsolateral prefrontal cortex of more than 500 brain samples demonstrating a small number of specific alterations on target genes such as EP300 that encodes p300, a histone acetyltransferase that regulates transcription in the cortex of subjects with AD.