CASP1 and metabolic dysfunction-associated steatohepatitis: Interestingly, this phenotype was also associated with a pronounced expression of PRRs, including toll like receptor 2 (Tlr2), toll like receptor 4 (Tlr4), toll like receptor 9 (Tlr9), NLR family, pyrin domain containing 3 (Nlrp3) and Caspase-1, which have all been implicated in the NASH pathogenesis (Figure 3E).