In order to overcome some of these limitations, some investigators have proposed a selection of expanded NK cell subpopulations expressing CXCR3, which increased migration toward solid tumors or genetic overexpression of CXCR2 to promote tumor homing as has been demonstrated in a renal cell carcinoma model [46,47,48]. This evidence concerns the gene CXCR3 and hereditary clear cell renal cell carcinoma.