VDR and colorectal cancer: It has been suggested that vitamin D receptor potentially mediates the protective effect of Vitamin D. A recent study, where data was pooled from 17 cohorts, involving 5706 colorectal cancer patients and 7107 control participants, revealed that higher circulating Vitamin D levels, lead to statistically significant decreased colorectal cancer risk in women and non-statistically significant reduction in men [21] (Table 3).