PIK3CA and colorectal carcinoma: In the multivariate analysis of the VICTOR study (a randomized trial comparing rofecoxib with placebo after primary CRC resection), stage II and III CRC patients with a PIK3CA mutation had a lower RFS when taking aspirin 100 mg daily (HR 0.11; 95% CI 0.001 to 0.832, p = 0.036) in the post-treatment setting [54].