HCRT and Prader-Willi syndrome: In addition, the LHA has unique neural elements and anatomical connections, serving as an interface between food consumption and reward.14 In PWS, postmortem studies suggest a relative preservation of orexin-positive cells in LHA.27 As patients with PWS have increased plasmatic levels of orexin A,28 we hypothesized that the modulation of local neuronal firing following DBS could have reduced orexin levels and food intake.