For example, the Hp 2-2 genotype is associated with greater risk of myocardial infarction.11 Because there were no differences herein in the prevalence of myocardial infarction among different genotypes, it is possible that the Hp 2-2 individuals in the ACCORD-MIND study may be those who survived a myocardial infarction. The gene discussed is HP; the disease is myocardial infarction.