Acute inflammatory reaction to infection or injury is a physiological process that is a defense mechanism of the body and is marked by an elevation of CRP levels; however, chronic low-grade inflammation is a pathologic process that may lead to chronic diseases such as cardiovascular disease.26 Although chronic low-grade inflammation was linked to high rates of mortality across all ApoE genotypes, an increased risk of AD was found only in ApoE4 carriers (Table 2, Figure 1, and Figure 2). Here, APOE is linked to Alzheimer disease.