Although chronic low-grade inflammation, based on a CRP level of 8 mg/L or higher, 9 mg/L or higher, or 10 mg/L or higher, was not found to be associated with AD or dementia, the interaction between ApoE4 and chronic low-grade inflammation was associated with AD or dementia (CRP level ≥9 mg/L: hazard ratio, 3.47; 95% CI, 1.10-10.94; P = .03) or tended to be positively associated with AD. The gene discussed is CRP; the disease is dementia.