APOE and Alzheimer disease: We also tested cutoff CRP levels of 8 mg/L or higher and 9 mg/L or higher to examine severity of chronic low-grade inflammation and found that they were all linked to onset of AD in the Kaplan-Meier analysis for carriers of ApoE4, but not for carriers of ApoE2 and ApoE3 (eFigure 2 in the Supplement).