APOE and Alzheimer disease: The interaction of ApoE4 and chronic low-grade inflammation, however, was negatively associated with the regions associated with AD pathologic characteristics (eg, temporal lobe brain volume: β = –0.78, SE = 0.25; P = .01) and persisted after adjusting for age and sex (temporal lobe brain volume: β = –0.85, SE = 0.22; P < .001) as well as after adjusting for age, sex, time to brain MRI, educational level, and cardiovascular disease (temporal lobe brain volume: β = –0.88, SE = 0.22; P < .001).