C-reactive protein (CRP) is an immune system response to toxins or injuries in systemic inflammation, while CRP levels increase with age.3 Although multiple AD-related genes are associated with the level of CRP,4 the association between blood CRP levels and risk of AD are not conclusive in the literature,5,6,7 with studies showing both low and high levels of CRP in patients with AD. This evidence concerns the gene CRP and Alzheimer disease.