PDE5A and premature ejaculation: The use ofoff-label antidepressant SSRIs to treat premature ejaculation is common; however,antidepressants can increase the risk of suicidal thinking and behavior in children,adolescents, and young adults.26,27 The FDA data show that anyoneconsuming sexual enhancement dietary supplements has the potential to be unknowinglyconsuming PDE5 inhibitors or SSRIs, risking interaction with other medications orpreexisting health conditions.