We also observed a marginal elevation in Ki67 with increasing stage, but no significant difference in Ki67 levels when comparing tumor size, LVI, or LN involvement (eg, mean [SEM], 29.9 [1.76] in tumor size >0.1 to ≤2.0 cm compared with 34.3 [3.5] in tumor size >5 cm; P = .82) (eFigure 6B-E in the Supplement). This evidence concerns the gene MKI67 and neoplasm.