For the secondary outcomes, the comparison of sulfonylureas with DPP-4 inhibitors, where study heterogeneity was low, showed a small increased hazard of myocardial infarction (consensus HR, 1.12; 95% CI, 1.02-1.24) and eye disorders (consensus HR, 1.15; 95% CI, 1.11-1.19) in the meta-analysis, although the recalibrated P values (eTable 18 in the Supplement) indicated that individually, at any 1 site the association was not significant (Table 2 and Figure 4B and D). This evidence concerns the gene DPP4 and eye disorder.