The HR was 0.67 (95% CI, 0.51-0.87) for patients with ER-positive cancers, 0.50 (95% CI, 0.32-0.78) for patients with ER-negative cancers, and 0.93 (95% CI, 0.77-1.13) for patients with unknown ER status. This evidence concerns the gene ESR1 and cancer.