KLK3 and Familial prostate cancer: Prior studies evaluated the diagnostic accuracy of bpMRI alone,24 combined with PSA levels,25 or compared with mpMRI.26 In a recent study of 161 biopsy-naive men who underwent bpMRI followed by targeted and standard biopsies, Jambor et al24 found that restricting biopsies to men with equivocal to highly suspicious bpMRI findings reduced the number of men undergoing biopsies by 24%, while failing to detect only 2% with significant prostate cancer.