GDF15 and metastatic malignant neoplasm in the lymph nodes: Furthermore, in the merged cohort of 495 patients with lymph node status (also described in materials and cut-off value of 1418 ng/L), high plasma level of GDF-15 was significantly associated with lymph node metastases (OR = 2.64; 95% CI 1.52–4.61) in univariate analysis.