The top hit was to the N-terminal winged helix domain of human rheumatic disease autoantigen La (pdb 1YTY; Z-score 7.1; rmsd of 3.8 Å at 72 Cα positions with 21% identity), an RNA-binding protein that recognizes the UUUOH 3′ termini of RNA polymerase III transcripts24. This evidence concerns the gene SSB and glycogen storage disease VI.