SHP2 is a well-established major regulator of RAS-to-RAF-to-MAPK signal pathway and somatic gain-of-function SHP2 mutations or overexpression have also been identified in several hematologic malignancies as well as solid tumors such as gastric, breast, lung and pancreatic cancers and RASopathies1,2,6,23–25. The gene discussed is PTPN11; the disease is familial pancreatic carcinoma.