OSM and neoplasm: These factors have roles in small intestine tissue regeneration, for instance, a ligand for intercellular signaling Notch pathway, JAG2 [49]; for growth and survival of connective tissue, PDGFC [48]; for stromal cell mitosis, proliferation smooth muscle cells, and endothelial cells in blood vessel (PDGFB) [50]; for proliferation of fibroblast (FBRS) [51]; for tumor suppression and liver development, angiogenesis, inflammation, and bone remodeling related factor oncostatin M (OSM) [52].