Consistent with the delivery efficiency studies, increased expression level of miR‐524 was observed in the cells treated with MDNP/dCas9–miR‐524 in acidic condition (Figure 3b,c), and the eventual downregulation of Smad2, Hes1, and Tead1 (Figure 3d,e) led to the significant loss in cell viability when incubating cancer cells with MDNP (Figure 3f,g). Here, SMAD2 is linked to cancer.