TGFB1 and neoplasm: By inhibiting the essential proteins for TGF‐β, Norch, and Hippo signaling pathways, MDNP/dCas9–miR‐524 effectively triggered the apoptosis of the tumor cells,21, 22 which was confirmed by the direct observation of the slices stained with hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase 2′‐deoxyuridine 5′‐triphosphate (dUTP) nick end labeling (TUNEL) (Figure 6c,d), respectively.