According to the RISH and IHC analyses, the tumor from the MDNP/dCas9–miR‐524‐treated mice exhibited remarkably higher miR‐524 expression level (Figure6a), which led to significant inhibition of the expression of Smad2, Hes1, and Tead1 (Figure 6b). This evidence concerns the gene SMAD2 and neoplasm.