The reasons we considered VPS53 as a key protein are as follows: (1) GZFLW can promote the expression of VPS53 and is 1.7 times higher than that of the control group, and it has statistical significance; (2) It has been reported that VPS53 can induce the release of cytochrome by inserting BAX into the mitochondrial membrane, which triggers the mitochondrial pathway and promotes cell apoptosis [21, 22]; (3) Inducing apoptosis of endometriosis stromal cells could suppress endometriosis progression [28–32]. The gene discussed is VPS53; the disease is endometriosis.