To gain some insight into the clinical relevance of HMGB1, we accessed the NCBI GEO database, accession GSE49711 (the MAQC-III/SEQC study) [28, 29], to adopt clinical and gene expression data of 498 pediatric neuroblastomas, focusing on determining the effects of HMGB1 expression in patient tumors associated with clinical outcomes (details in the Materials and Methods). Here, HMGB1 is linked to neuroblastoma.