AGTR1 and metabolic disease: Recent studies on the roles of gingerol extracts and gingerol, mainly in metabolic disorders, have drawn the following conclusions: gingerol extract decreases diet-induced obesity and increases endurance capacity through an increase in fat utilization via PPARδ signaling [10], and 6-gingerol mediates blood pressure effects through the inhibition of angiotensin II type 1 receptor (AT1R) activation [11], enhances glucose uptake via AMPK in differentiated L6 rat skeletal myocytes [12], and inhibits inflammation via AMPK activation in colitis [13].