Effector genes including Hif1a (HIF-1α), Irf7 (IRF7), Gzmb (granzyme B) and Gzmc (granzyme C), together with Cd47 as a control, were significantly downregulated in Cd47−/−, less than in WT NK cells upon infection (Figures 6C, 7A,B and Table S1). The gene discussed is IRF7; the disease is infection.