The significant downregulation of interferon signature genes, such as Adar (DRADA), Ddx58 (RIG-I), Ddx60 (DDX60), Stat1 (STAT1), Ifih1 (MDA5), Trim25 (TRIM25), Irf7 (IRF7), and Irf9 (IRF9) in infected Cd47−/− NK cells is consistent with the impaired Cd47−/− NK cell response to viral infection (Figure S7B). This evidence concerns the gene IFIH1 and viral infectious disease.