Comprehensive comparison of GSEA following infection showed significant downregulation of naïve (NES= −1.73, p < 0.001), early effector (NES= −1.96, p < 0.001) and interferon (NES = −2.09, p < 0.001) signature genes in CD47-deficient compared to WT NK cells (Figure 6D, Figure S7A, Table S2). Here, CD47 is linked to infection.