TP53 and cancer: While expression of mutant p53 alone results in addiction of cancer cells to the mutant protein for survival [26, 27], co-expression of both WT and mutant p53 in the heterozygous state leads to a DN effect of the mutant protein over the WT protein, leading to amelioration of the latter’s functions in target gene activation and apoptosis induction [19, 22, 23].