Importantly, si-p53 reduced cell death in WT p53-expressing HCT116 cells (si-scr vs. si-p53: 7.6 vs. 2.1), confirming that silencing of mutant p53 expression by a generic p53 siRNA or the mutation-specific siRNA leads to enhanced cell death only in mutant p53-expressing cancer cell lines. Here, TP53 is linked to cancer.