YWHAQ and psychotic disorder: This endophenotype is thought to represent the underlying neural circuit abnormalities of positive symptoms, as hyperactivity in rodents can be induced by drugs that cause psychosis in humans and can also be ameliorated by antipsychotics.32 Based on our previous analyses of the 14-3-3 FKO mice, the psychomotor disturbance is likely due to disruption of 14-3-3 functions in the forebrain region.15 In the present study, we used a viral-mediated approach to define the key forebrain regions that are involved in 14-3-3 inhibition induced psychomotor behavior.