YWHAQ and schizophrenia: Through further electrophysiological and biochemical analyses of these mice, we identified a reduction in post-synaptic NMDA receptors.15,30 Thus, these observations identified a potential substrate for 14-3-3’s actions at the synapse and are consistent with other reports showing that NMDA hypofunction in the forebrain leads to schizophrenia-associated behaviors, including hyperactivity.45,46 Here, we determined that acute 14-3-3 inhibition in specific forebrain regions also reduces NMDA receptor levels at the PSD.