KDM6A and cardiomyopathy: In order to study the effect of manipulating H3K27me3 levels on heart function, we next used heart-specific drivers to overexpress UTX. Cardiac-specific (GMH5-Gal4) or cardiac progenitor-specific (TinD-Gal4) dUTX expression effectively protected against cardiomyopathies due to acute or parental HFD exposure (Fig. 6c and Supplementary Figure 6a-e), as was observed by overexpressing bmm using these same drivers.