Additionally, heart dysfunction of PGC-1XP heterozygotes was rescued by a genomic construct (PGC-1GR20), as reported by Diop et al.16, thus providing strong evidence that cardiomyopathy observed in these PGC-1XP heterozygotes is due to loss of PGC-1 function. The gene discussed is PPARGC1A; the disease is cardiomyopathy.