Additional evidence of the functionality of 147 in the liver was evident in its ability to reduce hepatic triglycerides, which are a hallmark of hepatic steatosis, demonstrating improved ER proteostasis in the liver (Fig. 8d, blue); this beneficial effect of 147 was also lost upon deletion of ATF6 (Fig. 8d, black). The gene discussed is ATF6; the disease is fatty liver disease.