IGHE and allergic disease: Allergic diseases can potentially affect the course of pregnancy,1 and poorly controlled allergic diseases during pregnancy are associated with high mortality, low birth weights, and congenital malformations.2 Maternal sensitization to allergens also affects the onset of allergic diseases in children.3,4 This is because the maternal allergy is associated with an increase of cord blood immunoglobulin E (IgE),3 which can potentially induce T helper (Th) 2 shifts in the neonate,3,4 and these Th2 shifts may contribute to the development of allergies in subsequent children.4