The knockdown of lncRNA TP73-AS1 also reduces the expression of RFX1 and induces the apoptosis of glioblastoma multiforme cells [12], while TP73-AS1 promotes brain glioma growth and invasion by down-regulating HMGB1 via the sponging of miR-142 [14]. Here, TP73 is linked to brain glioma.