Constitutive overexpression of ING4 in human lung adenocarcinoma A549 cells significantly up-regulates the expression of p27 and down-regulates the expression of cyclin D1 and SKP2, suggesting that ING4 might inhibit cell proliferation by arresting cell cycle progression in late G1 via the Wnt-1/β-catenin signaling pathway [90]. The gene discussed is ING4; the disease is lung adenocarcinoma.