RELA and glioblastoma: Garkavtsev et al. [55] initially revealed that ING4 physically interacts with the p65/RelA subunit of NF-κB, forming a transcriptional complex that represses NF-κB-responsive genes such as interleukin (IL) 6 (IL-6), IL-8, cox-2, and CSF-3 in human glioblastoma U87MG cells.