A novel oncolytic vaccinia virus harboring ING4 (VV-ING4) also exhibits great cytotoxic efficiency, by induction of cell cycle arrest and apoptosis in pancreatic cancer cells, amongst others; the combination of VV-ING4 and gemcitabine demonstrates synergistic effects in vitro and in vivo [150]. Here, ING4 is linked to pancreatic neoplasm.