ING4 and central nervous system cancer: In contrast, recombinant adenoviruses, co-expressing ING4 along with a single gene such as PTEN, P53, or OSM, have shown a synergistic tumor-suppressive capacity in diverse cancers, including nasopharyngeal carcinoma, hepatocellular carcinoma, hypopharyngeal cancer, breast cancer, gastric cancer, and glioma, while simultaneously promoting chemosensitivity of hypopharyngeal cancer [141–148].