FBXO42 and breast carcinoma: Yan et al. [53] demonstrated that JFK-mediated destabilization of ING4 leads to hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer; in this process, JFK targets ING4 for ubiquitination and degradation through assembly of a Skp1–Cul1–F-box (SCF) complex.