NRG1 and cancer: In addition, 6 out of the 11 remaining cancer-protective loci which increase lifespan and pass FDR (near ZW10, NRG1, C6orf106, HNF1A, C20orf187, and ABO) also show significant associations with CVD but could not be tested for pleiotropy as we did not have data on the relative strength of association of every type of cancer against CVD, and thus (conservatively from the point of view of our conclusion) remain counted as cancer SNPs (Figure 7, Figure 7—source data 1).