The Alzheimer’s disease locus APOE shows the largest LVE (0.23 years2), consistent with its most frequent discovery as a lifespan SNP in GWAS (Joshi et al., 2016; Pilling et al., 2017; Deelen et al., 2014; Deelen et al., 2013). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.