Differentially methylated CpG probes in AMD cg26347887 (EIF2AK3), cg18486102 (FAIM2), cg01560972 (RIC3), cg26962595 (STARD10), cg11897517 (SMPD2), and cg04838987 (EDEM2) were associated with ATAC sequencing peaks in the RPE (Additional file 1: Table S12). This evidence concerns the gene EDEM2 and age-related macular degeneration.