SLC6A1 and schizophrenia: Subjects with schizophrenia exhibited expression deficits in GABA signaling-related mRNA transcripts; the downregulation of GAT1 in the presynaptic terminals of parvalbumin-containing chandelier neurons [92]; the upregulation of the GABAAR α2 subunit in the postsynaptic axon initial segments of pyramidal neurons [93]; deficits in GAD67 and VGAT [94]; neuropeptides (somatostatin, neuropeptide Y and cholecystokinin); and the GABAAR α1, α4, β3, γ2, δ [94, 95] and α5 subunits [96].