Importantly, the upregulated levels of SOX9 expression in SOX10 KD A375 (1.5 to 2.6 fold) and WM266–4 (1.5 to 3.4 fold) are clinical relevant as they fall within the range of SOX9 expression levels detected in some specimens of primary melanoma (1.3 to 3.7 fold) (Fig. 1e and Fig. 3c). This evidence concerns the gene SOX9 and melanoma.