SOX9 and melanoma: In conclusion, our findings unravel NEDD9 as a common transcriptional target for SOX10 or high SOX9 to partly mediate their oncogenic features in melanoma, and most importantly reconcile previous discrepancies that low or sub-optimal level of SOX9 expression dictates its anti-metastatic properties whereas high SOX9 is metastatic in a heterogeneous population of melanoma.