In this study, using antibodies specific for SOX9, SOX10, and NEDD9, we detected distinct but overlapping expression patterns of SOX10 and NEDD9 in nevi, primary and metastatic melanoma specimens, whereas SOX9 was predominantly and highly expressed in NEDD9+ metastatic melanoma in the small intestine and lung. This evidence concerns the gene SOX9 and metastatic melanoma.