The results showed that SOX10 KD and NEDD9 KD melanoma cells exhibited an increased number of vinculin+ focal adhesions together with larger average area and size per cell compared to the control that could result in enhanced focal adhesion contact with the substratum in vitro and reduced cell motility (Fig. 4d,e, Fig. 7a,b and Fig. 8b-d). This evidence concerns the gene VCL and melanoma.