CD8+ tumor infiltrating T lymphocytes (TILs) often express activation induced inhibitory receptors including CTLA-4 and PD-1 [4], while tumor cells frequently express immunosuppressive ligands, including PD-1 ligand 1 (PD-L1, also known as B7-H1 or CD274), that suppress T cell activation and effector function [5]. Here, CTLA4 is linked to neoplasm.