Genomic profiling of 23 available subjects also identified gene amplifications of cell cycle regulators (Cyclin D1, CDK4, or CDK6), fibroblast growth factors (FGF19, FGF3, and FGF4) and EMSY (a DNA repair inactivating gene) uniquely clustered in acral melanoma subjects in the study. The gene discussed is CDK4; the disease is melanoma.