IGHE and chronic rhinosinusitis: Several clinical trials have also explored the use of the Omalizumab in the treatment of other diseases in which IgE play a role (such as allergic rhinitis, food and drugs allergy, anaphylaxis, keratoconjunctivitis, urticaria, angioedema, allergic bronchopulmonary aspergillosis, atopic dermatitis, non-allergic asthma, Churg-Strauss syndrome, nasal polyposis, chronic rhinosinusitis, eosinophilic otitis media, bullous pemphigoid, contact dermatitis, mastocytosis) with promising results [30–32].