To identify BCP-ALL subtype-specific lncRNAs, we analyzed transcriptome profiles from paired initial diagnosis (ID) and relapse (REL) samples of 25 pediatric and 20 adult BCP-ALL patients lacking known chromosomal translocations like BCR-ABL, KMT2A, and ETV6-RUNX1. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.