These DUX4 relapse-specific lncRNAs showed correlation with the PC genes involved in vital signaling pathways and metabolic pathways, including NF-kappa B-signaling pathway, cell adhesion molecule (CAMS) and metabolic pathways (number of genes involved ≥ 3 and P value ≤ 0.05) (Fig. 3d, Additional file 4: Table S3). The gene discussed is DUX4; the disease is pachyonychia congenita.