DUX4 and acute lymphoblastic leukemia: For example, the DUX4 subtype is defined mainly by the IGH-DUX4 [8] gene fusions; the Ph-like subtype is a high-risk subtype with a gene expression profile similar to Ph-positive ALL, but lacking BCR-ABL1 fusion gene [9]; and the near haploid/high hyperdiploid (NH-HeH) (51–67 chromosomes) subtype is a common subtype [10, 11] comprising 30% of all pediatric BCP-ALL.