Beside retrieving the overlapping molecular processes informed by both GWAS and EWAS in conjunction with other functional evidence, our network modeling demonstrated that the psoriasis-associated pathways interconnect via network hub genes (Fig. 3), including both well-studied psoriasis genes involved in the immune system (HLA-A, ICAM1, IL15, STAT1, and TNFAIP3) and novel genes which may regulate immune processes and cell cycle (CTSH, GRB2, and IFITM2). The gene discussed is ICAM1; the disease is psoriasis.