As our multi-omics integration leveraged the full spectrum of disease association (from strong to moderate and subtle signals) as well as functional information such as eQTLs, ENCODE, pathways, and gene networks, we observed numerous novel processes for psoriasis, such as the BCAA, ER phagosome, and proteosome pathways in GWAS and the platelet and coagulation, lipid metabolism, insulin signaling, adipokine signaling, collagen formation, and cell-cell communication pathways in EWAS (Fig. 2). This evidence concerns the gene ARID4B and psoriasis.