Among the 62 KD subnetworks (36 KDs from the shared supersets and 26 KDs from the GWAS/EWAS-unique supersets),10 subnetworks showed significant up-regulation patterns in psoriasis vs control at FDR < 5%), including HLA-G, STAT1, TNFAIP3, BIRC3, TNFSF10, HLA-E, HLA-A, IL1B, LCK, and IL15 (Additional file 1: Table S11). This evidence concerns the gene LCK and psoriasis.