In the skin and blood psoriasis subnetworks, both existing (e.g., CCL2, IL8, CD2, LCK, SELL, PRKCQ, and STAT1) and potential drug targets (e.g., IL4R, IL1B, CCL20, CCL4, CCR7, CXCL10, CXCL9, CXCR4, IL7R, LYN, and TNFRSF21) [36, 41] were found to be closely connected via several KDs (TNFAIP3, STAT1, NFKB2, MCL1, LCK, IL15, IKZF1, and ICAM1) and are involved in immune system and cell migration. The gene discussed is CXCR4; the disease is psoriasis.