As an example, the YAP1 (Yes-associated protein)/TAZ (transcriptional coactivator with PDZ-binding motif) are reported to play an important role in tumor initiation and cancer progression, and may be proposed as prognostic biomarker in gastric, breast, ovarian, renal and prostate cancers (reviewed in [48]). The gene discussed is YAP1; the disease is prostate carcinoma.