Three genes were of special interest with regard to ccRCC progress; i.e. SMAD family member 6 (SMAD6, CpG cg10402698 and cg12476188), Suppressor of cytokine signaling 3 (SOCS3, CpG cg10279487 and cg27637521) and MX dynamin like GTPase 2 (MX2, CpG cg05656374 and cg15281283). The gene discussed is SMAD6; the disease is nonpapillary renal cell carcinoma.