Molecular variants in the SCN9A gene (MIM#603415) are responsible for a range of seizure disorders, which are characterized by early-onset isolated febrile seizures to generalized epilepsy with febrile seizures plus, type 7 (GEFS+), which identifies the most severe phenotype, as well as primary erythermalgia, callousness to pain linked to channelopathy and extreme paroxysmal pain disorder. This evidence concerns the gene SCN9A and generalized epilepsy.