In particular, mutations in hnRNPA1 associated to ALS [16], mutations in hnRNP D0/AUF1 identified in familiar cases of Crohn Disease [21] and mutations in hnRNP DL causing limb-girdle muscular dystrophy 1G [22] (Table 3). The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.