Thus, the aim of this study was to analyze the overall DNA methylation state of visceral adipose tissue (VAT), as well as the DNA methylation at the promoter regions of specific genes related to adipogenesis (PPARG, PPARA), lipid metabolism (RXRA, SREBF2, SREBF1, SCD, LPL, LXRb), and inflammation (LRP1 C3, LEP, and TNF) in subjects with and without MetS. The gene discussed is SREBF2; the disease is metabolic syndrome.