BCR and B-cell chronic lymphocytic leukemia: Herishanu et al. [58] through the comparison of gene expression profiles of CLL cells extracted from three different anatomic compartments (bone marrow, peripheral blood or lymph-node) have demonstrated that lymph-nodes represent the major site of CLL cells activation: here more than 100 genes, involved in BCR activation, NF-κB signaling or proliferation, were upregulated.