We demonstrated that the c-MET tyrosine kinase inhibitor SU11274 or the neutralizing anti-HGF moAb L2G7 (a kind gift from Galaxy Biotech, Sunnyvale, CA 94089, USA) counteracted increased CLL cells viability induced by HGF treatment or after co-culturing leukemic cells with specific stromal cells (BMSC, trabecular bone cells, the osteoblasto-like cell line MG63 [21] and Figure 1). This evidence concerns the gene HGF and B-cell chronic lymphocytic leukemia.