HGF and B-cell chronic lymphocytic leukemia: We here describe how the HGF/c-MET axis is involved in a complex scenario taking place in different hematological malignancies: we will deepen details relative to the CLL microenvironment to explicit how HGF, produced within the stroma by different mesenchymal cell types and by the CLL cells themselves, contributes to increase viability of the c-MET+ leukemic clone and further affects differentiation of surrounding cells, leading to suppression of normal immune responses.