Recently, Kim demonstrated the effects of Costaria costata extract on atopic dermatitis via suppressing expression of TARC, eotaxin, TNF-α, and IL-6 in TNF-α and IFN-γ-stimulated HaCaT keratinocytes as well as release histamine in PMA and A23187-stimulated MC/9 mast cells [45]. Here, TNF is linked to atopic eczema.