MMP14 and cancer: Among the large repertoire of extracellular matrix (ECM) and basement membrane components cleaved by MT1-MMP are the adhesion molecules and fibrillar proteins fibronectin, vitronectin, laminins, collagens I, II and III [4,5] as well as key signalling molecules implicated in cancer dissemination such as CD44, syndecan-1, RANKL and MUC1 [6,7,8,9].