For example, Giordano et al. [22] inferred thyroid cancer associated point mutations in BRAF and RAS genes, which might be driven by the fusion of RET, NTRK1 and ALK. Interestingly, NTRK1 and ALK were also inferred to be up-regulated differentially expressed genes in our study, which increase the confidence of our differential genes. Here, BRAF is linked to thyroid cancer.